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. 2010 Mar 24;5(3):e9846. doi: 10.1371/journal.pone.0009846

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Uemura et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, Possible outcome of Cre-mediated recombination between two loxP sites with an identical orientation in the same chromosome 14. Site1 was targeted to the IGHA2 locus within the IgH gene cluster. Site2 was targeted to a region tentatively designated 104, 1.1 Mb centromeric to the IGHA2 loci. B, Results of representative two cis-targeted (NSK122 and NSK126) and two trans-targeted clones (NSK107 and NSK108) are shown. The chromosomes 14 with Site1 and Site2 integration harbor red and green signals, respectively, and are highlighted with boxes, magnifications of which are shown in insets.