Skip to main content
. Author manuscript; available in PMC: 2010 Sep 14.
Published in final edited form as: Behav Brain Res. 2009 Apr 5;202(2):238–244. doi: 10.1016/j.bbr.2009.03.039

Figure 1.

Figure 1

The mGluR5 selective antagonist MTEP attenuates reinstatement of cocaine seeking. A) Mean number of active lever responses on last day of cocaine self-administration, extinction and during the reinstatement of drug seeking by a cocaine priming injection (10 mg/kg, i.p.). B) Responses on active and inactive levers following the administration of vehicle (1% DMSO) or varying concentrations of MTEP. MTEP dose-dependently attenuated cocaine priming-induced reinstatement of cocaine seeking. The asterisks represent significant differences from vehicle (p< 0.05, Tukey’s HSD). Inset: Systemic MTEP had no influence on the reinstatement of sucrose seeking. C) Average of active lever responses on last day of cocaine self-administration using a second-order schedule of reinforcement [FI5(FR5)]. Mean of active lever responses on the last day of extinction and during cue-induced reinstatement of cocaine seeking also are depicted. D) MTEP dose-dependently attenuated cue-induced reinstatement of cocaine seeking. The asterisk represents a significant difference from vehicle pretreatment (p<0.05, Tukey’s HSD). All data are expressed as mean (± SEM) active or inactive lever pressing per session.