Fig. 2.

Effect of MMP-2 on Phe- and AngII-induced IVC contraction in Ca²⁺ free Krebs. Rat IVC segments nontreated or treated with MMP-2 (1 μg/ml) were incubated in Ca²⁺-free (2 mM EGTA) for 5 min. The tissues were stimulated with Phe (10^-5M) (A) or AngII (10^-6M) (B) and the peak of the transient contraction was measured as an indicator of the intracellular Ca²⁺ release mechanism from the sarcoplasmic reticulum. Data represent means±SEM of 3-16 measurements.