Table 2.
Glucocorticoid-Mediated Changes in Gene Expression in T-Cell Acute Lymphoblastic Leukemia Patient Samples
| Gene | TALL1 | TALL2 | TALL3 | TALL4 |
|---|---|---|---|---|
| Bim | 19.87 | 1.44 | 9.08 | 3.66 |
| GILZ | 5.79 | 11.60 | 27.91 | 11.92 |
| c-Jun | 3.29 | 1.54 | 3.20 | 4.88 |
| PKARIIβ | 19.18 | 1.88 | 1.58 | 1.57 |
| Total GR | 1.19 | 2.26 | 3.78 | 1.58 |
| PU.1 | 1.55 | 0.88 | 1.44 | 2.74 |
| JunB | 1.03 | 1.02 | 2.49 | 2.71 |
| p21 | 0.76 | 0.46 | 1.84 | 1.97 |
| FOXO3a | 1.41 | 1.22 | 1.29 | 1.32 |
| Granzyme A | 1.33 | 0.64 | 1.28 | 2.42 |
| Bcl-2 | 1.36 | 0.97 | 2.51 | 0.83 |
| c-Myb | 1.66 | 0.74 | 1.07 | 0.90 |
| Mcl-1 | 1.02 | 0.95 | 1.25 | 1.54 |
| MKK3 | ✘ | 0.63 | 1.40 | 0.89 |
| Granzyme B | 1.59 | 0.46 | 0.94 | 0.62 |
| p16INK | ✘ | 0.30 | 1.40 | 0.38 |
| AIF1 | 0.79 | 0.65 | 0.95 | 0.75 |
| PUMA | 1.16 | 0.16 | 1.17 | 0.74 |
| p38 MAPK | 0.68 | 0.96 | 1.23 | 1.20 |
| c-Abl | 1.02 | 0.90 | 1.24 | 1.12 |
| Bcl-XL | 0.86 | 1.14 | 1.10 | 0.94 |
| ERK2 | 1.15 | 0.86 | 0.99 | 1.17 |
| Spi-B | 1.09 | 0.90 | 0.94 | 0.99 |
| PGC-1 | ✘ | ✘ | ✘ | ✘ |
The absence of an entry (✘) indicates that the expression of the transcript was not detectable. All values are normalized to a set of 4 normalization genes (see text), and the expression of the transcript in the presence of hormone is divided by its expression in cells treated with the ethanol vehicle alone (control). The numbers, thus, are fold changes in dexamethasone-treated samples compared to control values. The cut-off values are as follows: up-regulated transcripts (≥1.3-fold; red); no change in transcript levels (> 0.7-fold and <1.29-fold; yellow); down-regulated (<0.7-fold; green).