Fig. 2.

PbAE/PLGA polymer-blend nanoparticles for temporal-controlled delivery. a Illustration of polymer-blend nanoparticle design, whereby the pH-responsive poly(beta-amino ester) (PbAE) internalizes into a matrix of slow-releasing poly(d,l-lactice-co-glycolide) (PLGA) to compartmentalize paclitaxel away from C6-ceramide within the particle, leading to controlled release of the two drugs. b Scanning electron micrographs of the polymer-blend nanoparticles at low resolution (left panel) and high resolution (right panel). c Release profile of PTX (solid line) and CER (dashed line) from the polymer-blend nanoparticles at pH 7.4 for the first 6 h and at pH 6.5 for the remainder of the release study. The arrow indicates a drop in pH from 7.4 to 6.5. (n = 3 repeats/nanoparticle type)