Fig. 3.

Effect of high storage temperature on the immunogenic potency of the vaccines. Vaccines were stored for 3 months at 40°C and subsequently injected in mice. Serum H5N1-specific IgG titers (a) and HI titers (b) were determined, and are shown as geometric mean titers + SEM. Immunization groups are labeled as in Fig. 1. The group immunized with liquid WIV, which had not been subjected to the storage experiment, serves as a standard. *p < 0.05 when compared with the standard; ^# p < 0.05 ^## p < 0.01 when compared with liquid WIV stored at 40°C