. 2010 Mar 3;12(2):202–214. doi: 10.1208/s12248-010-9177-1

Table II.

Results of Partial Least Square Regression Analysis for Predicting the Drug, Phospholipid, and Stearylamine Percentages as well as Percentages of Drug Released After 1 and 8 h Using Three PLS Factors

	Tenofovir (%)		Phospholipon (%)		Stearylamine (%)		Q 1hour (%)		Q 8hours (%)
	Cal.	Val.	Cal.	Val.	Cal.	Val.	Cal.	Val.	Cal.	Val.
Slope	0.9822	0.9633	0.9959	0.9851	0.9958	0.9886	0.9734	0.9681	0.9918	0.9854
Offset	0.0987	0.2026	0.2145	0.7898	0.0385	0.1112	0.2769	0.3181	0.3244	0.5552
Correlation (R ²)	0.9910	0.9870	0.9979	0.9965	0.9979	0.9964	0.9866	0.9808	0.9959	0.9936
RMSE	0.3691	0.4448	0.3077	0.4046	0.1967	0.2569	0.7679	0.9186	1.2359	1.5477
SE	0.3787	0.4563	0.3157	0.4151	0.2018	0.2635	0.7879	0.9423	1.2680	1.5877
Bias	1.4e⁻⁷	−0.001	21.5e⁻⁶	−0.004	−4.3e⁻⁷	0.005	−7.15e⁻⁸	−0.014	9.5e⁻⁷	−0.027

Cal. calibration, Val. validation, Q 1hour and Q 8hours percentages of drug released after 1 and 8 h, respectively, RMSE root mean square error, SE standard error