Fig. 7.

External PD predictions of the baseline-subtracted ADAS-Cog measurements: observed concentrations (circles) and calculated median, fifth and 95th percentiles (solid lines) from simulations are shown over time for the 0.25 (a), 0.5 (b), 1.0 mg (c), and placebo (d) dose group. Box-whisker plot (e) (box 25th, 50th, and 75th percentile, whiskers tenth and 90th percentile, open circles fifth and 95 percentile) of observed (OBS) and simulated (SIM) ADAS-Cog values at week 14 of the 0.25, 0.5, 1.0 mg, and placebo dose group