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Activation of estrogen-responsive reporter plasmids by resveratrol in MCF-7 cells. (A) MCF-7 cells were transfected with ERE-tk109-luc, incubated with the indicated amounts of estradiol or resveratrol, and assayed for luciferase activity as described above. (B) Comparisons of estradiol, resveratrol, and DES using different reporter genes. (C) Effect of combined estradiol and resveratrol in the activation of ERE-tk109-luc. Results are shown as mean ± SEM for triplicate transfections.
