Change in suppressor of cytokine signaling (SOCS)-3 (A and B) protein in mononuclear cells (MNC) after intake of a 900-kcal high-fat, high-carbohydrate meal and a 300-kcal drink of orange juice (OJ+meal), glucose (Glu+meal), or water (W+meal) in normal subjects. Values in B are means ± SEs. *,**P < 0.05 [repeated measures ANOVA (RMANOVA)] compared with baseline values after W+meal, Glu+meal, or OJ+meal, respectively. P for interaction (treatment × time) = 0.364. n = 10 each.