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Co-release of CGRP with glutamate from presynaptic neurons (for example, a peripheral nociceptor) could act presynaptically to further increase neurotransmitter release and/or postsynaptically to increase glutamate receptor activity. In addition, CGRP could act in a paracrine fashion on nearby glia (lower left cell) and/or dural mast cells (not shown) to indirectly act on the neurons.
