Table 1.

Effects of genetic deletion/modification of Akt isoforms or its regulatory proteins in platelets.

Mouse model	Defect in sensitivity to agonists	Effect on Akt phosphorylation	Effect on platelet function	Ref.
Akt1 −/−	Collagen, thrombin		Reduces calcium release, aggregation and hemostasis (increases tail-bleeding time)	[6]
Akt2 −/−	PAR4 agonist, ADP		Reduces aggregation, secretion and thrombosis in carotid artery injury model	[5]
PI3Kβ KD	ADP, thromboxane A2 (U46619), glycoprotein VI agonist	Decrease	Reduces platelet aggregation, adhesion and spreading on fibrinogen	[66]
PI3K γ −/−	ADP	Decrease	Reduces maximal ADP aggregation	[63,64]
	ADP	No change	Reduces maximal ADP aggregation	[65]
			Reduces response to arterial injury model of thrombosis, thromboembolism	[63,64]
PI3Kγ KD	ADP, thromboxane A2 (U46619)	Decrease	Reduces aggregation	[66]