Table 2.
Metabolite ratios by MRI classification and developmental outcome
| Metabolite ratios in thalamus and basal ganglia |
|||||
|---|---|---|---|---|---|
| na | Ch/Cr (mean±s.d.) | NAA/Cr (mean±s.d.) | NAA/Ch (mean±s.d.) | ||
| MRI | Normal | 14 | 2.46±0.36 | 0.99±0.16 | 0.41±0.06 |
| Abnormal | 5 | 2.67±0.43 | 1.04±0.14 | 0.40±0.06 | |
| MDI | Normal | 12 | 2.47±0.30 | 1.02±0.14 | 0.42±0.06 |
| Abnormal | 7 | 2.60±0.49 | 0.98±0.19 | 0.38±0.05 | |
| PDI | Normal | 14 | 2.49±0.33 | 1.00±0.13 | 0.41±0.07 |
| Abnormal | 4 | 2.54±0.58 | 1.00±0.27 | 0.39±0.06 | |
| Metabolite ratios in cortex | |||||
| MRI | Normal | 23 | 2.50±0.42 | 1.11±0.25 | 0.45±0.11 |
| Abnormal | 10 | 2.44±0.24 | 1.09±0.16 | 0.46±0.09 | |
| MDI | Normal | 22 | 2.47±0.40 | 1.12±0.24 | 0.46±0.09 |
| Abnormal | 11 | 2.49±0.31 | 1.08±0.20 | 0.44±0.12 | |
| PDI | Normal | 24 | 2.49±0.39 | 1.15±0.23 | 0.47±0.11 |
| Abnormal | 7 | 2.50±0.22 | 1.02±0.12 | 0.41±0.05 | |
Abbreviations: Ch, choline; Cr, creatine; MDI, mental developmental index; MRI, magnetic resonance imaging; NAA, N-acetylaspartate; PDI, psychomotor developmental index.
a
Satisfactory metabolite spectra were not available for all infants in each region of interest.