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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: J Immunol. 2010 Jan 8;184(4):1675–1679. doi: 10.4049/jimmunol.0903539

Figure 4. TGFβ1 controls γδ T cell IL-17 expression.

Figure 4

(A and B) γδ T cell cytokine production from Tgfβ1−/− (A), Smad3−/− (B), and littermate control mice was determined. Shown are the mean ± SD of 4~6 individually tested mice. (C and D) Thymic cells from 11-day old Tgfβ1−/− and littermate control mice were examined for DN subset distribution based on CD44 and CD25 expression (C), or stimulated and IL-17 expression of γδ TCR+ thymocytes in each DN subset was examined (D). Shown is the mean ± SD of 4 individually tested mice. (E) FACS sorted DN γδ TCR- (DN), DP, CD4 SP (4SP), and DN γδ TCR+ thymocytes were examined for Tgfβr1 and Tgfβr2 expression by real time PCR. *, p<0.05; **, p<0.01; ***, p<0.001.