TABLE 1.
Results of laboratory tests in C57BL/6 mice and apoE−/− mice after 28-day treatment with exendin-4
| C57BL/6 |
ApoE−/− |
|||||
|---|---|---|---|---|---|---|
| Control | Low Ex4 | High Ex4 | Control | Low Ex4 | High Ex4 | |
| Total cholesterol (mg/dl) | 66.7 ± 2.6 | 70.5 ± 1.4 | 73.9 ± 2.2* | 522.3 ± 26.3 | 472.6 ± 22.8 | 437.2 ± 30.0* |
| LDL cholesterol (mg/dl) | 6.62 ± 0.42 | 6.33 ± 0.25 | 7.30 ± 0.59 | 136.5 ± 8.2 | 126.4 ± 7.5 | 138.4 ± 4.9 |
| HDL cholesterol (mg/dl) | 56.6 ± 2.0 | 61.0 ± 1.2 | 63.3 ± 1.5* | 16.9 ± 0.8 | 16.1 ± 1.0† | 19.0 ± 0.9 |
| TGs (mg/dl) | 42.9 ± 4.4 | 41.3 ± 3.3 | 37.6 ± 5.9 | 52.7 ± 4.2 | 54.7 ± 4.1 | 62.3 ± 4.2 |
| CM (mg/dl) | 5.95 ± 1.02 | 7.24 ± 1.13 | 4.35 ± 1.02 | 63.9 ± 4.4 | 61.6 ± 2.3 | 55.5 ± 4.2 |
| Sd-LDL (mg/dl) | 1.18 ± 0.07 | 1.16 ± 0.04 | 1.22 ± 0.09 | 27.0 ± 1.7 | 25.3 ± 1.7 | 29.2 ± 1.1 |
| A1C (%) | NA | NA | NA | 3.46 ± 0.20 | 3.64 ± 0.17 | 3.38 ± 0.12 |
Data are mean ± SE. Blood samples were collected from C57BL/6J mice (n = 6) and apoE−/− mice (n = 13 except for HbA1C, n = 6 for HbA1C) in the fasting state after 28-day treatment with exendin-4.
*P < 0.05 vs. control group.
†P < 0.05 for low Ex4 vs. high Ex4. Low Ex4, low-dose exendin-4; High Ex4, high-dose exendin-4; TG, triglycerides; CM, chylomicron; Sd-LDL, small, dense LDL; HbA1c, A1C; NA, not applicable.