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. 2010 Jan 12;59(4):894–906. doi: 10.2337/db09-1024

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Upregulation of Socs3 in leptin receptor neurons does not result in obesity when fed a high-fat diet. A: Control and LepRb-Socs3-OE mice were placed on a high-fat diet (60% kcal from fat; Research Diet D12492) at 5 weeks of age for a total of 16 weeks (controls n = 16–19, mutants n = 9–10). B: Body length (nose to anus) of control and mutants was identical after 16 weeks on high-fat diet (controls n = 11, mutants n = 6). C: Body composition analysis by DEXA after 16 weeks on high-fat diet (controls n = 14, mutants n = 8). D: Weight of individual fat pads after 16 weeks on high-fat diet (controls n = 13, mutants n = 9). Data represent mean ± SEM. WAT, white adipose tissue.

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