FIG. 8.

Effects of Socs3 upregulation on glucose homeostasis. A and B: POMC-Socs3-OE and control mice at 8 weeks (A) or 25 weeks (B) of age were fasted for 6 h and injected with 1.5 g/kg glucose. Glucose levels were measured from tail blood using a glucometer. Area under the curve (AUC) was presented. Control n = 32 (A), n = 6 (B); mutants n = 19 (A), n = 5 (B). C and D: LepRb-Socs3-OE and control mice at 5 (C) or 9–11 (D) weeks of age were fasted for 6 h, and injected with 1.5 g/kg glucose. Glucose levels were measured from tail blood using a glucometer. AUC was presented. Control n = 9–11, mutants n = 7–10. Data represent mean ± SEM. *P < 0.05 between controls and mutants. Analysis was performed by Student t test.