FIG. 6.

RMCs regulate hepatic TG accumulation in the presence of excess lipid. Hepatic expression of hCCL2 and expansion of the RMC content did not alter insulin sensitivity (A) or liver mass (B) of mice on LFD or HFD (n = 4). C: Increased recruitment of RMCs did not increase hepatic TG in LFD-fed mice but did induce steatosis in mice with excess lipid intake (□, Ad-LacZ; ■, Ad-hCcl2). D: Hepatic expression of hCCL2 and recruitment of RMCs increased histologically visible hepatic steatosis and lipid droplets in HFD-fed mice (bar = 50 microns). *P < 0.05.