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RMCs promote expression of lipogenic genes. A: Increased recruitment of RMCs through hepatic expression of hCCL2 increased lipogenic gene expression in HFD-fed mice (□, Ad-LacZ; ■, Ad-hCcl2). B: Deficiency of CCR2 in weight-matched mice fed an HFD for 9 weeks reduced lipogenic gene expression (□, CCR2+/+; ■, CCR2−/−) (n = 13). Data represent mean ± SD. *P < 0.05; **P < 0.01. AU, arbitrary units.
