TABLE 1.

Effects of CB1 antagonism on body composition, serum, and liver parameters

	CON group	HSHF group	HSHF+SR group
n	5	10	14
Organ weight
Liver (g)	1.38 ± 0.03*	1.49 ± 0.06†	1.21 ± 0.03‡
Epididymal fat (g)	0.67 ± 0.14*	2.04 ± 0.16†	0.98 ± 0.07‡
Inguinal fat (g)	0.31 ± 0.06*	1.10 ± 0.10†	0.41 ± 0.03*
Serum
Glucose (mg/ml)	2.79 ± 0.16	2.72 ± 0.21	2.53 ± 0.08
Insulin (ng/ml)	0.40 ± 0.03*	0.59 ± 0.07†	0.44 ± 0.03*
Adiponectin (μg/ml)	63.05 ± 3.24*	42.31 ± 7.21†	59.82 ± 3.95*
FFAs (mmol/l)	0.30 ± 0.04*	0.54 ± 0.06†	0.43 ± 0.03‡
Triglycerides (mg/ml)	0.74 ± 0.06*	0.36 ± 0.03†	0.31 ± 0.02†
Total cholesterol (mg/ml)	1.09 ± 0.04*	2.05 ± 0.07†	1.87 ± 0.06†
Liver
Glycogen (mg/g)	66.7 ± 8.1*	49.2 ± 4.2†	37.4 ± 3.0‡
Triglycerides (mg/g)	24.4 ± 4.5*	118.7 ± 17.6†	46.4 ± 4.9‡
Total cholesterol (mg/g)	16.07 ± 0.94	17.98 ± 1.63	15.72 ± 0.7
Malonyl CoA (nmol/g)	1.67 ± 0.29*	3.43 ± 0.52†	2.41 ± 0.18‡

Data are means ± SE. Mice were fed an HSHF diet for 25 weeks, receiving during the last 6 weeks either 10 mg · kg⁻¹ · day⁻¹ of the CB1-specific antagonist SR141716 (HSHF+SR) or the vehicle (HSHF diet). In parallel, a series of mice was maintained on a control diet (CON group). Mice were food deprived 4 h before tissue handling.

*,†,‡Statistically different at P < 0.05.