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. 2010 Jan 27;59(4):935–946. doi: 10.2337/db09-0404

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 7. — OPN neutralization downregulates expression of hepatic gluconeogenic markers. Obese high-fat diet–fed (HF) mice were treated with OPN-neutralizing or control antibody (n = 8 per group). Hepatic mRNA expression of genes encoding GSK-3β (Gsk3b) (A) and the gluconeogenic enzymes PEPCK (Pck1) (B) and G6P (G6pc) (C) was analyzed. *P ≤ 0.05.