. Author manuscript; available in PMC: 2011 Mar 1.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Jan 20;20(5):1767–1770. doi: 10.1016/j.bmcl.2010.01.036

Table 2.

D-ring substitutions can enhance biological activity. The lack of activity against the ΔtarO strain indicates specificity for the WTA biosynthetic pathway.

graphic file with name nihms178684u2.jpg

Compds	R¹	R²	Wildtype S. aureus MIC (μM)	ΔtarO S. aureus MIC (μM)
15	H	H	1.8	na ^a
37	H	CH₃	2.5	na
38	H	Cl	0.3	na
39	CH₃	Cl	2.5	na

na [not active] indicates <30% growth inhibition at 100 μM.