Table 1.
Antigens Expressed on Pediatric Tumors
| ANTIGEN | PEDIATRIC TUMORS | REFERENCE |
|---|---|---|
| MAGE-1, -2, -3 | gliomas, medulloblastoma, neuroblastoma, osteosarcoma | 2–4 |
| GAGE | gliomas, medulloblastoma, neuroblastoma, ESFT | 2–5 |
| BAGE | AML | 2, 6 |
| XAGE | ESFT, alveolar rhabdomyosarcoma | 7 |
| NY-ESO-1 | Synovial sarcoma, osteosarcoma, neuroblastoma | 2, 8, 9 |
| PRAME | AML, Wilms tumor, neuroblastoma | 6, 10–12 |
| N-Myc | neuroblastoma | 13, 14 |
| Proteinase-3 | CML, AML, MDS | 15, 16 |
| WT1 | AML, ALL, rhabdomyosarcoma | 6, 17, 18 |
| Survivin | “universal” | 19–21 |
| Telomerase (hTERT) | “universal” | 20, 22, 23 |
| translocation breakpoints | Synovial sarcoma t(X;18); CML t(9;22), ALL t(12;21), DSRCT t(11;22), alveolar rhabdomyosarcoma t(2;13) | 24–27 |
| Mutant p53 | Variable across histologies | 28, 29 |
| HBV and HCV | Hepatocellular carcinoma | 30 |
| EBV EBNA2, 3 | EBV lymphoproliferative disorder | |
| EBV EBNA1, LMP-1, -2 | Hodgkin’s, nasopharyngeal carcinoma, EBV lymphoproliferative disorder, Burkitt lymphoma | 31, 32 |