Model 3 is an alternate multi-stage model of progression from cannabis availability to cannabis initiation (β1) and from initiation to abuse (β2). Progression from cannabis availability to diagnoses can also be one of direct, rather than mediated, causal influence (β3). In Model 4, this parameter is predicted to be non-significant i.e. β3 = 0.
Note: A=Addition genetic variance, C=Common or shared environmental variance, E=Non-shared environmental variance