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TH is a component of inclusion bodies formed by expression of mutant torsinA. Midbrain neurons transduced with vectors encoding ΔE302/303 were stained for torsinA (green), TH (red) and either MAP2 (blue; a-d) or PDI (blue; e-h). TH was recruited to inclusions as evidenced in the merged images (d,h), whereas neither MAP2 or PDI demonstrated significant overlap with the inclusions. Scale bar = 20μM (d) and 10μM (h) respectively.
