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. Author manuscript; available in PMC: 2011 Apr 19.
Published in final edited form as: Auton Neurosci. 2009 Nov 3;154(1-2):14–19. doi: 10.1016/j.autneu.2009.09.023

Figure 5.

Figure 5

The effects of α4β2 nAchRs antagonist DHβE on nicotine-induced responses. A. Raw recordings of responses induced by nicotine, showing a prominent parasympathetic bradycardic response with little sympathetic pressor response (left), while pre-administration of DHβE largely blocked the parasympathetic bradycardic response (right). B. Mean data showing that, compared with the nicotine alone (open bars), pre-administration of DHβE (solid bars) significantly attenuated the nicotine induced decrease in heart rate (bottom) with no effect on the pressor response (top) and the increase in HR (middle). The vertical dotted lines in the recording traces showed the relative positions of injections. “*” indicate P<0.05 compared with the nicotine only group. n= 5