Table 2.
Conditional and unconditional changes ± SD in mBP and HR for CS+ for Drug Group in Protocol 1
| Days 1 - 3 (Saline) | Days 4 - 6 (Atomoxetine) | |
|---|---|---|
| mean Arterial BP (mm Hg) | ||
| pre-tone baseline | 128 ± 11 | 117 ± 19* |
| peak initial change (pk C1) | +9.4 ± 7.5 | +10.1± 4.2 |
| avg. initial change (avg. C1) | +4.0 ± 3.7 | +3.8 ± 4.2 |
| avg. time to peak C1 (tpkC1, sec) | 16.7 ± 0.9 | 17.5 ± 1.1* |
| avg. sustained change (C2) | +4.6 ± 3.5 | +4.2 ± 3.8 |
| unconditional response (UR) | +27.5 ± 12.5 | +25.7 ± 8.7 |
| Heart Rate (bpm) | ||
| pre-tone baseline | 380 ± 23 | 351 ± 21* |
| peak change during C2 | +23.0 ± 15.2 | −26.3 ± 26.5* |
| avg. sustained change (C2) | +7.4 ± 17.8 | −2.3 ± 10.7 |
= p < 0.05, saline vs. atomoxetine See Figure 1 for definitions of pk C1, avg C1, C2 and UR.