Table 3.
Conditional and unconditional changes ± SD in mBP and HR for CS+ for Saline and Drug Groups in Protocol 2
| Saline | Atomoxetine | |
|---|---|---|
| mean Arterial BP (mm Hg) | ||
| pre-tone baseline | 111 ± 12 | 107 ± 9 |
| peak initial change (pk C1) | +6.6 ± 1.7 | +8.0 ± 4.5 |
| avg. initial change (avg. C1) | +3.4 ± 1.1 | +4.0 ± 2.6 |
| avg. time to peak C1 (tpkC1, sec) | 16.1 ± 0.8 sec | 17.1 ± 1.1* |
| avg. sustained change (C2) | +3.0 ± 2.3 | +4.1 ± 3.3 |
| unconditional response (UR) | +27.2 ± 15.2 | +25.1 ± 8.8 |
| Heart Rate (bpm) | ||
| pre-tone baseline | 372 ± 20 | 345 ± 12* |
| peak change during C2 | +13.3 ± 18.3 | −17.2 ± 8.0* |
| avg. sustained change (C2) | +7.5 ± 14.7 | −6.2 ± 10.5* |
= p < 0.05, saline vs. atomoxetine See Figure 1 for definitions of pk C1, avg C1, C2 and UR.