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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Epilepsia. 2009 Aug 8;51(3):465–468. doi: 10.1111/j.1528-1167.2009.02248.x

Figure 1. Injection paradigm and seizure scores of SUDEP model.

Figure 1

(A) Injection paradigm of SUDEP model. (B) Averaged seizure scores are shown of animals with pretreatment of EHNA (10 mg/kg, i.p.) and ITU (3.1 mg/kg, i.p.) (EI-K, n=9), or saline (SAL-K, n=9) followed by kainic acid injection (35mg/kg, i.p.). * P<0.01 (one-way ANOVA). The green box indicates initially enhanced seizure suppression by potentiation of the kainic acid-induced adenosine (ADO) surge; the red box indicates the SUDEP phase. All mice in the EI-K group died within 30 to 45 minutes after kainic acid injection.