Table 2.

Correlations between CSF Kynurenine and Kynurenine Metabolites and Immune Variables

Immune Measure	KYN (nM)	QUIN (nM)	KA (nM)
IFN-alpha (pg/ml)	0.62***†	0.42*	0.28
sTNFR2 (ng/ml)	0.48*†	0.56**†	0.46*
IL-6 (pg/ml)	0.26	0.16	0.01
sIL-6R (ng/ml)	0.36	0.37	0.36
MCP-1 (ng/ml)	0.59**†	0.45*	0.34

KYN: L-kynurenine; QUIN: quinolinic acid; KA: kynurenic acid; IFN: interferon; sTNFR2: soluble tumornecrosis factor-alpha receptor 2; IL: interleukin; sIL-6R: soluble IL-6 receptor; MCP-1: monocyte chemoattractant protein-1; n=25-27 Values reported as Spearman's rho

^*-p<0.05

^**-p<0.01

^***-p<0.001

^†-p<0.05 after controlling for multiple comparisons (Holm-Bonferroni method)