Fig. 2.

Exon 12 −/− mice are impaired in the ledge test compared to WT mice. Mice were placed on the 0.75 cm-wide ledge of a mouse cage and observed for 3 min. Mice were scored as having performed one of four behaviors: remaining stationary on the ledge, falling off the ledge, climbing into the cage in a controlled manner, or progressing along the ledge. a Average distance progressed by mixed lineage WT and Exon 12 −/− mice. b Percent of mixed lineage mice to perform each behavior. c Average distance crossed by 129 Sv lineage Exon 12 −/− and WT mice. d Percent of 129 Sv lineage mice to perform each behavior. Data are represented as a percentage of the total number of mice tested. Error bars are ±SEM, significant difference is indicated by * (P < 0.05 for the same behavior compared between WT and Exon 12 −/− of the same lineage)