Fig. 5.

Behavioral analysis of mixed-lineage Exon 12 −/− mice indicates normal spatial learning and mild anxiety. Mixed-lineage mice were tested for anxiety in the open-field maze and spatial learning and anxiety in the Barnes maze. Open-field measurements included (a) center-to-wall time ratio, (b) total distance traveled in centimeters, (c) the amount of ambulatory time. The Barnes maze measurements included (d) the percentage of mice that entered the goal box, (e) the percentage of mice finding and investigating the goal, (f) the average time to find and investigate the goal for all trials, and (g) the average time to find the goal for each trial. For Barnes maze data, the number of mice to accomplish the task is represented as a percent of the total number tested. Error bars are ±SEM. Significance of P < 0.05 is indicated by *