Table 3.

Multivariate associations between cortisol and late-life cognition and estimated cognitive change^*

	Unadjusted		Model 1		Model 2		Model 3		Model 4
			+Sex and age		+MHVS		+Other covariates†		+Interactions‡
	β§	P	β	P	β	P	β	P	β	P
MR	−0.04	0.28	−0.03	0.46	−0.04	0.18	−0.05	0.08	NSI
LNS	−0.06	0.07	−0.05	0.13	−0.07	0.04	−0.07	0.02	−0.44	0.002
VFT	0.04	0.27	0.04	0.21	0.03	0.36	0.02	0.51	NSI
DST	−0.06	0.07	−0.05	0.13	−0.07	0.03	−0.06	0.04	NSI
lnTMT	0.05	0.13	0.04	0.24	0.05	0.09	0.05	0.12	NSI
FACES	−0.05	0.13	−0.05	0.08	−0.06	0.09	−0.06	0.07	NSI
LM	0.04	0.20	0.05	0.16	0.04	0.27	0.05	0.13	NSI
g	−0.05	0.20	−0.03	0.37	−0.05	0.09	−0.05	0.06	−0.30	0.015

*Cognitive test scores adjusted for MHVS.

†Other covariates = HADS score, duration of diabetes, A1C, total cholesterol, BMI, hypertension, smoking, alcohol intake, myocardial infarction, angina, stroke, ABI, and level of education.

‡Interactions between plasma cortisol and covariates were tested for all models. Significant interactions were included in the LNS model (cortisol by ABI: β = 0.572, P = 0.002; cortisol by alcohol intake: β = −0.436, P = 0.001) and the g model (cortisol by ABI: β = 0.331, P = 0.038).

§Standardized β. NSI, no significant interactions.