Table 2.
Association of rs2237897 with diabetic nephropathy in four independent Japanese studies
| Population | Case |
Control |
P * | OR (95% CI)* | |||
|---|---|---|---|---|---|---|---|
| Phenotype | RAF | 11/12/22 | RAF | 11/12/22 | |||
| Initial study | Overt proteinuria | 0.33 | 331/336/81 | 0.27 | 294/210/48 | 0.0027 | 1.30 (1.09–1.54) |
| Replication 1 | Overt proteinuria | 0.32 | 209/188/50 | 0.30 | 473/404/82 | 0.156 | 1.13 (0.95–1.34) |
| Replication 3 | Overt proteinuria | 0.32 | 14/13/3 | 0.28 | 79/61/13 | 0.617 | 1.16 (0.64–2.11) |
| Meta-analysis† | 1.4 × 10−3 | 1.21 (1.08–1.36) | |||||
| Replication 2 | End-stage renal disease | 0.33 | 133/132/33 | 0.28 | 111/98/14 | 0.080 | 1.28 (0.97–1.68) |
| Meta-analysis (all studies)‡ | 3.08 × 10−4 | 1.22 (1.10–1.34) | |||||
| Meta-analysis (replication 1–3)§ | 0.03 | 1.16 (1.01–1.34) | |||||
*Unadjusted data.
†Meta-analysis was performed by Mantel-Haenszel test (heterogeneity P = 0.51).
‡Meta-analysis was performed by Mantel-Haenszel test (heterogeneity P = 0.70).
§Meta-analysis was performed by Mantel-Haenszel test (heterogeneity P = 0.79). RAF, risk allele frequency; 11, homozygous of major allele; 12, heterozygous; 22, homozygous of minor allele.