Figure 5.

Cajal's histological preparations and drawings showing some contributions to the pathology of the Nervous System. (A) Degeneration of nerve fibers (reduced silver nitrate); (B) Experiment of ligadura in the peripheral nervous system (reduced silver nitrate); (C) Senile plaques and neurofibrillary tangles in Alzheimer's disease (reduced silver nitrate and ammoniacal silver oxide); (D) “dementia praecox” in Purkinje cell with asteriform apparatus (reduced silver nitrate); (E) Neurofibrils in a motoneuron in a dog with rabies, reduced silver nitrate; (F) Giant astrocytes in a man with progressive general paralysis (ammoniacal silver oxide); (G) Rod microglia cells of a man with progressive general paralysis (ammoniacal silver oxide). (Drawings reproduced with the permission of the Inheritors of Santiago Ramón y Cajal ©).