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. 2010 Mar 22;188(6):821–832. doi: 10.1083/jcb.200911086

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© 2010 Zito et al.

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Figure 3. — Impaired glucose tolerance and glucose-stimulated insulin secretion in ERO1-β mutant mice. (A) Fasting blood glucose of male mice of the indicated age and indicated ERO1-β genotype. Shown are the mean and SEM in each group; also shown (in small black dots) are the glucose measurements of the individual mice in each group (*, P < 0.001). (B) Fasting blood glucose and blood glucose to serum insulin ratio of 6-mo-old male mice with the indicated ERO1-β genotype. Shown are the mean and SEM in each group (n = 5; *, P < 0.001 by two-tailed t test). (C) Blood glucose levels after intraperitoneal injection of a glucose load into 6-mo-old male otherwise-isogenic C57BL/6; 129 F1 hybrid wild-type and heterozygous ERO1-β mutant mice. Shown are the mean and SEM in each group (n = 5; *, P < 0.001 by two-way ANOVA). (D) Blood glucose to serum insulin ratio at the fasted and 15-min time point of the experiment shown in C. Shown are the mean and SEM in each group (n = 5; *, P < 0.001 by two-tailed t test) and the measurement on each individual animal in small black circles.