Table 5.
Multivariate adjusted RR and 95% CI for the association between baseline vigorous physical activity and endometrial cancer by BMI, NIH-AARP Diet and Health Study
| Vigorous physical activity during typical month in past 12 months | No. cancers | Person- years | RR* | 95% CI | p for trend | RR § | 95% CI | p for trend | p for interaction |
|---|---|---|---|---|---|---|---|---|---|
| BMI <25 | |||||||||
| Never/Rarely | 53 | 59,559.7 | 1.00 | 0.92 | 1.00 | 0.21 | 0.12 | ||
| 1–3 times/month | 37 | 44,116.1 | 0.98 | (0.65, 1.50) | 0.89 | (0.59, 1.36) | |||
| 1–2 times/week | 70 | 73,250.7 | 1.10 | (0.77, 1.58) | 0.97 | (0.68, 1.38) | |||
| 3–4 times/week | 102 | 102,612.0 | 1.13 | (0.81, 1.58) | 0.93 | (0.67, 1.31) | |||
| 5+ times/week | 62 | 77,168.1 | 0.91 | (0.63, 1.32) | 0.76 | (0.52, 1.10) | |||
| BMI 25+ | |||||||||
| Never/Rarely | 239 | 102,762.5 | 1.00 | <.0001 | 1.00 | <.0001 | |||
| 1–3 times/month | 112 | 66,374.3 | 0.76 | (0.61, 0.95) | 0.76 | (0.61, 0.95) | |||
| 1–2 times/week | 151 | 89,366.7 | 0.74 | (0.61, 0.91) | 0.73 | (0.60, 0.90) | |||
| 3–4 times/week | 142 | 92,733.5 | 0.66 | (0.53, 0.81) | 0.66 | (0.53, 0.81) | |||
| 5+ times/week | 77 | 52,909.1 | 0.62 | (0.48, 0.80) | 0.61 | (0.47, 0.79) | |||
Relative risks adjusted for age (continuous)
Relative risks adjusted for age (continuous), race (white vs. other/unknown), smoking status (never, former, current, or unknown), parity (nulliparous, one, two, ≥ three births, or unknown), ever use of oral contraceptives (no, yes, unknown), age at menopause (premenopausal, natural menopause at <45, 45–49, 50–54, or ≥ 55 years of age, or unknown age at menopause), and ever use of hormone therapy (no, yes)
Not shown are unknown vigorous activity among women with BMI <25 (1 cancer and 2,362 person-years) and unknown vigorous activity among women with BMI 25+ (6 cancers and 2,956 person-years).
BMI, body mass index; CI, confidence interval; RR, relative risk