TABLE 2.
Obese Without T2DM n = 9 |
Obese With T2DM n = 21 |
|
---|---|---|
Age (yr) | 37.4 ± 7.5 | 46.1 ± 9.2* |
Weight (kg) | 121.1 ± 19.3 | 114.1 ± 15.3 |
BMI (kg/m2) | 45.5 ± 7.1 | 45.1 ± 8.1 |
Fasting glucose (mmol/L) | 5.34 ± 0.48 | 7.87 ± 1.29* |
Fasting insulin (pmol/L) | 167.9 ± 86.4 | 195.2 ± 97.9* |
HOMA-IR | 4.81 ± 2.57 | 8.67 ± 4.60* |
Fasting GLP-1T (pmol/L) | 5.23 ± 3.60 | 5.99 ± 3.27 |
Peak GLP-1T (pmol/L) | 10.1 ± 5.2 | 16.9 ± 11.5 |
Fasting ghrelin | 409 ± 112 | 516 ± 243 |
Max sup ghrelin (%) | 24.6 ± 13.5 | 15.9 ± 11.2 |
Nadir ghrelin (pg/mL) | 315 ± 124 | 428 ± 177 |
Fasting leptin (ng/mL) | 39.7 ± 11.5 | 34.6 ± 14.0 |
Fasting PYY3–36 (pg/mL) | 39.9 ± 21.1 | 64.1 ± 34.5* |
Peak PYY3–36 (pg/mL) | 50.2 ± 24.8 | 78.9 ± 39.1* |
AUC PYY3–36 (pg/mL/min−1) | 30.0 ± 20.8 | 59.9 ± 32.2* |
Mean ± SD.
Denotes significant difference between groups, P < 0.05.
Max sup ghrelin indicates maximal suppression of ghrelin; AUC, area under the curve.