Table 2.

Table 2A Comparison of gene gun and pipette infections of H. CRPV and H. CRPV E8ko in rabbits. Each of ten rabbits was infected as follows: L(left side)1, L3: E8ko via gene gun; L2, L4, H. CRPV via gene gun; R(right side)1, R3, E8ko via pipette; R2, R4, H. CRPV via pipette. Sites L1, R1 and L2, R2 received no scarification prior to infection. Sites L3, R3 an L4, R4 were scarified three days prior to infection.
Infections by gene gun	DNA	Infections by pipette delivery	DNA	Scarification at day -3?
L1	E8M	R1	E8M	No
L2	wt.H.	R2	wt. H.	No
	CRPV		CRPV
L3	E8 M	R3	E8M	Yes
L4	wt. H.	R4	wt. H.	Yes
	CRPV		CRPV

Table 2B Positive papilloma sites at week 11 following infection on rabbits infected with H. CRPV and the E8ko as shown in table 1A. Note that all animals experienced the gene gun although only half of the infections were initiated by gene gun.
Gene gun Delivery Site Scarification?	Genome	Paps/ total infection sites Week 11	Pipette Delivery Site Scarification?	Genome	Paps/ total infection sites Week 11
L1 no	E8M	1/10	R1 no	E8M	2/10
L2 no	W.T.	1/10	R2 no	W.T.	4/10
L3 yes	E8M	1/10	R3 yes	E8M	2/10
L4 yes	W.T.	5/10	R4 yes	W.T.	8/10