Table 1.

Summary of signaling and developmental defects reported for primary T cells expressing mutant forms of SLP-76.

Domain	Mutation name	Defective signaling	Developmental defects	Defects in peripheral T-cell function
Amino terminus	ΔSAM-SLP-761	Ca2+ flux, pErk	Thymic size, DP → SP, (+) and (−) selection	Proliferation, IL-2 production, SLP-76 clustering
	Y3F2	pSLP-76, pPLCγ1, Ca2+ flux	Thymic size, DN3 → DN4, DP → SP	CD69/CD25 up-regulation, proliferation, TCR clustering
	Y112/128F3	pSLP-76, pVav1, pPLCγ1, Ca2+, pErk, actin	DP → SP, (+) and (−) selection, Nur77 upregulation	Not reported
	Y145F3	pPLCγ1, Ca2+, pErk, actin	DP → SP, (+) and (−) selection, Nur77 up-regulation, ↑CD8SP with memory/innate markers	Not reported
PRR	Gads Binding Mutant2,4	pPLCγ1, Ca2+	Thymic size, DP → SP, (+) selection	CD69/CD25 up-regulation, proliferation, TCR clustering
	P15*	pPLCγ1, Ca2+, pErk	n.d.	n.d.
	Lck6	pPLCγ1, Ca2+, pErk	Thymic size, DN3 → DN4, DP → SP	CD25 up-regulation, proliferation, IL-2 production
SH2	R448K2,7	pSLP-76 Ser376, pPKD,	DN3 → DN4, DP → SP, (+) selection	CD69/CD25 up-regulation, proliferation, IL-2 production

1. Shen et al. 2009.

2. Myung et al. 2001.

3. Jordan et al. 2008.

4. Jordan et al. 2007.

*Data reported for cell lines.

5. Yablonski et al. 2001.

6. Kumar et al. 2005.

7. M. S. J. unpublished data.