Figure 3.

Linkage disequilibrium (LD) plot of SNPs in the ADIPOQ region spanning 50kb (positions 188030-188080kb). The grey shading of the diamonds represent the pair-wise D′ and the numbers in the diamonds represent the pair-wise r² between the two SNPs defined by the top left and the top right sides of the diamond. The figure clearly shows that the top-hit rs17366568 is located within an own LD block and shows virtually no correlations with any other SNP in the entire 50kb region. The columns on the right side of the Figure show i) whether a particular SNP is genotyped by the Affymetrix 500K chip (A) or the Illumina HumanHap300 chip (I); all other SNPs are imputed; ii) the z-scores and iii) the p-values for each SNP-adiponection association for the combined analysis of the cohorts ERF, KORA and MICROS; iv) SNPs that are correlated with an r²>0.60 are grouped in groups 1-9.