Table 1.

Genome-wide significant association of the rs17366568 (G>A) SNP in the ADIPOQ locus

			Combined			Women			Men
Population	EAF*	Rsqr†	n	Beta‡	P	n	Beta‡	P	n	Beta‡	P
Stage 1
ERF	0.91	0.37	1817	0.103	2.7E-07	1052	0.115	1.0E-05	765	0.088	0.004
KORA	0.89	0.91	1643	0.173	1.7E-15	830	0.204	1.9E-11	813	0.142	5.8E-06
MICROS	0.90	0.27	1195	0.114	3.0E-06	678	0.102	4.1E-04	517	0.182	1.6E-05
Combined**	0.90	-	4655		4.3E-24	2560		8.7E-17	2095		2.5E-11
Stage 2
Colaus	0.88	1.00	5261	0.132	3.0E-13	2759	0.119	1.1E-06	2502	0.146	5.1E-08
Framingham	0.88	1.00	2220	0.072	0.003	1213	0.050	0.108	1007	0.094	0.012
GEMS	0.87	1.00	1780	0.149	2.9E-06	732	0.084	0.095	1048	0.194	2.1E-06
ALSPAC	0.92	0.37	1415	0.395	2.9E-14	691	0.453	9.4E-09	724	0.351	3.5E-07
TWINS UK	0.998	NA	1399	0.154	0.078	1399	0.154	0.078	-	-	-
InChianti	0.94	NA	1027	-0.056	0.481	562	-0.130	0.268	465	0.007	0.95
BLSA	0.92	0.61	565	0.263	0.004	266	-0.028	0.822	299	0.488	2.5E-04
Combined**	0.89	-	13667	-	5.2E-22	7622	-	2.7E-10	6045	-	8.1E-14
Stage 1 + 2
Combined**	0.89	-	18322		1.1E-41	10182		2.8E-22	8140		7.8E-23

^*EAF = effect allele frequency (i.e. frequency of G) for sex-combined analysis

^†Rsqr = imputation certainty

^‡Beta estimate from linear regression adjusted for age, BMI, and (if appropriate) for sex per unit change [log(μg/mL)] for the risk allele G

^**Results are provided for a beta-pooling meta-analysis using the fixed effect model weighting for the inverse variance. When a scaling-invariant p-value pooling meta-analysis using the sample size weighted z-score method was applied for sensitivity analysis, we found no major differences between both methods.