Table 2. Heritability and percentage of variance explained by the ADIPOQ locus SNPs.
Heritability of plasma adiponectin in the family-based study MICROS and percentage of plasma adiponectin variance (KORA) explained by the ADIPOQ locus SNPs in KORA (region on chr 3, position 188.030 – 188.080kb).
| Combined | Women | Men | |
|---|---|---|---|
| Heritability (%) in MICROS | |||
| no SNP adjustment | 59.6 | 65.1 | 54.0 |
| adjusted for top hit rs17366568 | 58.4 | 64.6 | 51.5 |
| adjusted for “independent ”SNPs (n=9) a | 52.9 | 55.1 | 48.1 |
| % of variance of plasma adiponectin in KORA explained by | |||
| top hit rs17366568 | 3.8 | 5.3 | 2.4 |
| for “independent” SNPs (n=9) a | 5.9 | 6.3 | 5.1 |
| all SNPs with MAF >5% (n=33) b | 6.7 | 6.4 | 5.5 |
Computations were based on standardized sex-combined or sex-specific residuals of plasma adiponectin adjusted for age (and sex if applicable) and BMI without and with additional SNP adjustment; includes only SNPs with MAF>5% available in all three studies.
Among the SNPS of the ADIPOQ region with MAF > 5% and available in all three GWA studies: selecting the SNP with the smallest p-value from each bin of SNPs with pairwise r2>0.2: rs1063539, rs16861194, rs17300539, rs17366568, rs17366743, rs3774261, rs6810075, rs7615090, rs822394
All SNPS of the ADIPOQ region with MAF > 5% and available in all three GWA studies: rs6810075, rs10937273, rs12637534, rs1648707, rs864265, rs822387, rs16861194, rs17300539, rs266729, rs182052, rs16861205, rs16861209, rs822391, rs16861210, rs822394, rs822396, rs12495941, rs7649121, rs17366568, rs2241767, rs3821799, rs3774261, rs3774262, rs17366743, rs6773957, rs1063537, rs2082940, rs1063539, rs7639352, rs6444175, rs7628649, rs17373414, rs9860747, rs1501296, rs7615090