TABLE 1.
Anteriorly or posteriorly enriched transcripts with a function in chromatin regulation
| Name (symbol) | Subcluster | Function, location, interaction |
|---|---|---|
| Posterior eye-disc fragments vs. reference sample | ||
| anti-silencing factor (asf1) | Anterior | Chromatin architecture |
| cup (cup) | Anterior | Chromosome organization, negative regulation of translation |
| Dodeca-satellite-binding protein 1 (Dp1) | Anterior | Heterochromatin formation, chromatin remodeling |
| High mobility group protein D (HmgD) | Anterior | Chromatin architecture |
| Heterogeneous nuclear ribonucleoprotein at 87F (Hrb87F) | Anterior | Chromatin, ribonucleoprotein complex |
| osa (osa) | Anterior | Chromatin remodeling, Trithorax group |
| Poly-(ADP-ribose) polymerase (Parp) | Anterior | Chromosome organization, regulation of transcription |
| reptin (rept) | Anterior | Chromatin remodeling, Ino80 complex, DNA helicase activity |
| Suppressor of variegation 3-7 [Su(var)3-7] | Anterior | Heterochromatin |
| CG3371 | Posterior | Chromosome, centromeric region |
| enhancer of yellow 3 [e(y)3] | Posterior | Chromatin remodeling |
| enhanced adult sensory threshold (east) | Posterior | Chromosome segregation |
| Protein on ecdysone puffs (Pep) | Posterior | Chromosome puff, spliceosome, ribonucleoprotein complex |
| tonalli (tna) | Posterior | tna chromatin-mediated maintenance of transcription, genetic interaction with osa |
| enhancer of yellow 3 [e(y)3] | Subcluster III | Chromatin remodeling |
| lola like (lola) | Subcluster III | Chromatin silencing |
| Minichromosome maintenance 5 (Mcm5) | Subcluster III | DNA replication, chromosome condensation |
| DSIF (spt4) | Subcluster III | Noncovalent chromatin modification; positive regulation of transcription |
| Posterior fragments + stop furrow mutants + extra R8 mutants vs. reference sample | ||
| Additional sex combs (Asx) | Subcluster IV | Chromatin silencing, Polycomb group |
| CG40351 | Subcluster IV | Histone-lysine N-methyltransferase |
| Dodeca-satellite-binding protein 1 (Dp1) | Subcluster IV | Heterochromatin formation, chromatin remodeling |
| jumeau (jumu) | Subcluster IV | Chromatin architecture, transcription factor |
| osa (osa) | Subcluster IV | Chromatin remodeling, Trithorax group |
| Sex comb on midleg (Scm) | Subcluster IV | Chromatin silencing, Polycomb group |
| Suppressor of variegation 3-3 [Su(var)3-3] | Subcluster IV | Heterochromatin formation |
| Suppressor of zeste 2 [Su(z)2] | Subcluster IV | Chromatin silencing, Polycomb group |
The analysis of posterior eye-disc fragments and the comparison with different mutant eye imaginal discs (compare text) identified genes involved in the regulation of chromatin structure and chromatin-based transcriptional regulation. The genes in boldface type were also identified in the study by Jasper et al. (2002) (Table S7).