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. 2010 Apr;24(4):1178–1191. doi: 10.1096/fj.09-139147

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Figure 1. — Injection of MOP-NMP nanoparticles into P5 and P22 rds^+/− animals increases Rds mRNA levels. cDNA samples from eyes injected with saline, naked DNA, or nanoparticle DNA at P5 (A) or P22 (B) and from PI-2 through PI-120 were prepared and analyzed by qRT-PCR to determine relative Rds mRNA levels. Because Rds primers amplify both native (endogenous) and transgenic (exogenous) Rds genes, expression values are reported as fold change relative to the uninjected contralateral eye (control). Values are averages ± se (n=3–6 mice/group). Injection of nanoparticles at P5 (A) or P22 (B) led to statistically significant increases in Rds mRNA levels. Naked DNA and saline injection did not lead to any increase compared with the contralateral uninjected control eye. There was no significant difference between mRNA levels from eyes injected with nanoparticles at P5 and P22. *P < 0.01.