Table 1.
Association of Genetic Risk Score and Family History with Cardiovascular Disease
| Base Model | 101 SNP Genetic Risk Score a | 12 SNP Genetic Risk Score b | Family History of Premature MI | |||
|---|---|---|---|---|---|---|
| HR per allele (95% CI) | p-value | HR per allele (95% CI) | p-value | HR (95% CI) | p-value | |
| Age | 1.02 (1.00, 1.03) | 0.006 | 1.05 (1.01, 1.09) | 0.014 | 1.67 (1.39, 1.03) | <0.001 |
| ATP III covariates c | 1.00 (0.99, 1.01) | 0.63 | 1.04 (1.00, 1.08) | 0.052 | 1.57 (1.31, 1.89) | <0.001 |
| Reynolds covariates d | 1.00 (0.99, 1.01) | 0.76 | 1.04 (1.00, 1.07) | 0.06 | - | - |
a
Includes SNPs (single nucleotide polymorphisms) associated with incident cardiovascular disease and intermediate phenotypes
b
Includes only SNPs associated with incident cardiovascular disease
c
Age, systolic blood pressure, hypertensive medication use, smoking, diabetes, total and high density lipoprotein cholesterol
d
Age, systolic blood pressure, smoking, diabetes, total and high density lipoprotein cholesterol, c-reactive protein, family history of premature myocardial infarction