Table 2.

Discrimination and Reclassification after Addition of Genetic Risk Score or Family History to Base Model

Base Model		101 SNP Genetic Risk Score a				12 SNP Genetic Risk Score b				Family History of Premature MI c
		Discrimination		Reclassification		Discrimination		Reclassification		Discrimination		Reclassification
	C Index	C Index	p-valued	NRI	p-valuee	C Index	p-valued	NRI	p-valuee	C Index	p-valued	NRI	p-valuee
Age	0.701	0.704	0.14	1.2	0.13	0.705	0.01	0.6	0.52	0.709	0.013	3.1	0.02
ATP III covariates f	0.793	0.793	0.92	0.5	0.24	0.794	0.12	0.5	0.59	0.796	0.059	1.4	0.28
Reynolds covariates g	0.796	0.796	0.84	0.4	0.21	0.796	0.12	0.8	0.36	-	-	-	-

^aIncludes SNPs (single nucleotide polymorphisms) associated with incident cardiovascular disease and intermediate phenotypes

^bIncludes only SNPs associated with incident cardiovascular disease

^cParental MI (myocardial infarction) before age 60

^dP-value is for comparison with the base model c-index

^eP-value is compared to the null NRI of 0% or equal reclassification correctly and incorrectly

^fAge, systolic blood pressure, hypertensive medication use, smoking, diabetes, total and high density lipoprotein cholesterol

^gAge, systolic blood pressure, smoking, diabetes, total and high density lipoprotein cholesterol, c-reactive protein, family history of premature myocardial infarction