Table 3.

Reclassification Calibration for the Addition of Genetic Risk Score or Family History to Base Model

Base Model	101 SNP Genetic Risk Score a				12 SNP Genetic Risk Score b				Family History of Premature MI c
	Chi2 Base	p-value	Chi2 Plus	p-value	Chi2 Base	p-value	Chi2 Plus	p-value	Chi2 Base	p-value	Chi2 Plus	p-value
Age	9.9	0.13	8.9	0.18	5.9	0.44	4.8	0.56	16.9	0.01	3.6	0.73
ATP III covariates d	11.6	0.009	11.6	0.009	14.7	0.04	14.2	0.05	22.1	0.005	13.3	0.10
Reynolds covariates e	4.1	0.25	4.1	0.25	9.4	0.15	8.4	0.21	-	-	-	-

^aIncludes SNPs (single nucleotide polymorphisms) associated with incident cardiovascular disease and intermediate phenotypes

^bIncludes only SNPs associated with incident cardiovascular disease

^cParental MI (myocardial infarction) before age 60

^dAge, systolic blood pressure, hypertensive medication use, smoking, diabetes, total and high density lipoprotein cholesterol

^eAge, systolic blood pressure, smoking, diabetes, total and high density lipoprotein cholesterol, c-reactive protein, family history of premature myocardial infarction