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Mechanism of β-lap redox cycling. (A)β-Lap undergoes a futile redox cycle in an NQO1-dependent manner. The hydroquinone form is unstable and through two one-electron oxidation steps converts back to the parent β-lap form. This cycling “bioactivates” β-lap and results in the generation of Reactive Oxygen Species (ROS). (B) Schematic of complexation and incorporation of β-lap and β-lap·HPβ-CD complexes into PLGA millirods.
