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. Author manuscript; available in PMC: 2010 Mar 25.
Published in final edited form as: Clin Cancer Res. 2009 Jan 1;15(1):131–139. doi: 10.1158/1078-0432.CCR-08-1691

Fig. 2.

Fig. 2

β-Lap killed human prostate cancer cells in an NQO1-dependent mechanism. (A) NQO1 protein expression levels in various human prostate cancer cell lines. LNCaP cells are DNA mismatch repair deficient (25) and one clone was isolated with an NQO1-deficiency. Cells were transfected with NQO1, creating an isogenic NQO1+/− system (4). (B) Relative survival assays of three different cell lines exposed to either β-lap alone at the indicated doses or β-lap + concomitant dicoumarol (40 μM) for 2 h. Error bars represent standard error of means (SEM) from six replicates performed each in duplicate.